Evotec Reports Positive Clinical Trial Results for the repositioning of its CNS-active substance

Hamburg, Germany - Oxford, UK - Evotec AG (German Stock Exchange: EVT,
TecDAX 30) today announced that the study was to reposition its
CNS-active substance (see press release dated 18 March 2005) completed
with positive results.

The clinical trial study in healthy volunteers was performed to
confirm the substance as a potential new drug for the treatment of
insomnia. The preliminary results of this study indicate that the
substance is well tolerated, both in terms of sleep duration and sleep
quality showed significant efficacy. After-effects the following
morning were hardly observed.

Joern Aldag, CEO of Evotec commented: "The positive results of
Repositionierungsstudie us confident to proceed with the clinical
development program, Evotec has the sole commercial rights to the
compound, EVT called 201, which is an essential part of our CNS
development pipeline now.. We are pleased that today our major goal,
the first substance to the end of 2005 to begin the clinical
development, have reached. This is an important step in implementing
our strategy to develop a sustainable CNS pipeline. It shows our
performance in implementing our business model. "

The substance acts on GABA A receptors and has a different
pre-clinical profile of action compared with conventional sleep
medications. It was originally developed by Roche, which was a
clinical phase I study carried out successfully. This is the second
program, Evotec has in-licensed from Roche.

Notes - insomnia

Good and refreshing sleep is a basic requirement for health and
performance. Insomnia patients suffer from a) difficulty falling
asleep; b) staying asleep, ie waking up frequently during the night
with difficulty falling asleep or waking up again in the early morning
hours and c) not a good night's sleep. Approximately 50% of the
population regularly symptoms of insomnia are observed. However, only
a fraction of patients are diagnosed and even fewer using a sleep aid.
However, the market for sleeping pills in the U.S. of U.S. $ 1.4
billion in 2002 to U.S. $ 1.7 billion in 2003, has grown (source:
IMS). According to a Credit Suisse First Boston with leading
therapists sleep study (January 2005), the market for sleeping pills
are still not fully developed and promises sustained growth. The
doctors emphasize that the key success factors lie in the clinic is to
develop new sleeping pills that do not produce residual effects the
next day and no potential dependence and also have the ability to
maintain or improve the quality of sleep. They assume that the market
entry of new drugs with differentiated profiles in terms of dosage,
mode of action and clinical characteristics will accelerate the growth
of the market.

Evotec AG

Evotec is a leader in drug discovery and development. In our own
research programs and through contract research partnerships, the
highest quality research results to its partners in the pharmaceutical
and biotechnology industries. In proprietary projects, Evotec
specializes in finding new therapies for the treatment of diseases of
the central nervous system (CNS). Your drug EVT 201 is used to treat
insomnia in Phase I clinical development. In addition, the company
holds a portfolio of products in late preclinical development. The
most advanced project, EVT 101, a subtype selective NMDA receptor
antagonist for the treatment of Alzheimer's disease, should reach the
end of 2005 into clinical development. In contract research, Evotec
has established itself as a preferred partner for pharmaceutical and
biotechnology companies. The Company provides a fully integrated
offering innovative solutions from drug target to clinic through.
Their services range from providing assay development and screening
through to optimization of chemical substances in medicinal chemistry
and drug manufacturing. With over 600 people in Hamburg, Germany, and
Oxford and Glasgow, UK, Evotec is ideally positioned to carry their
business strategy, the short-and long-term business opportunities
Evotec to create value for partners, shareholders and employees.

SFA: sleeping killer alcohol - which is why he keeps us from sleeping

Lausanne (Switzerland) - The nightcap in the evening barbecue has
its pitfalls. The alcohol alters the sleep and ensures particularly in
the second half of the night to wake phases. He changed the sleep
rhythm, headache or sweating promotes and encourages snoring. Worse in
people with breathing disorders during sleep which he complaints. The
Swiss Institute for Alcohol and Drug Problems (SIPA) offers tips for a
deep sleep.

Summer time is party time. The long hours of sunshine and mild
temperatures in the night hours lead to staying up, and feasts to
celebrate with friends. So some wonder if the beer sausage for a
nightcap or more of a killer is sleeping. The research confirms the
personal experience, which accelerates the alcohol to fall asleep
sooner. Despite falling through the alcohol as a sleep aid: How to
make unpleasant after-effects associated with the noticeable
degradation of alcohol in the body. Going to the toilet comes to mind,
sleep is superficial. After moderate drinking one night
Schwitzattacken, headaches, nightmares, or dry mouth may plague scare
away sleep. High and regular use is often accompanied by insomnia.

Alcohol promotes snoring men who have consumed alcohol before
going to sleep snore more often. The reason: After the alcohol relaxes
the muscles of the airways. This makes the breathing on the way to the
lungs to a greater resistance. Inhalation is tedious and snoring
increases. This can lead to short interruptions in breathing, even for
people who suffer from a sleep otherwise. Several research also show
that alcohol can aggravate sleep-related breathing disorders.
Excessive consumption, especially in the evening, can encourage the
sleep apnea syndrome. Typical of this disease are brief interruptions
of breathing during sleep, which are caused by narrowed airways.
Affected are often sleepy and exhausted on the day. Anyone suffering
from breathing disorders at night should abstain from alcohol before
going to bed and generally pay attention to a moderate consumption.

As the true sleep aids sleeping pill is not worth of alcohol. But
there is comfort in addition to good sleep, as do dark and quiet in
the bedroom, room temperature at 18 degrees and a suitable mattress,
several strategies to get something for a deep sleep. These include:
regular bedtimes. Evening stress, excitement, and avoid heavy foods.
Rituals maintain e.g. a reading before falling asleep. Day care for
your outdoor activities.

The SFA will soon For the Swiss Institute for Alcohol and Drug
Problems (SIPA) is the protection of the health center. The SFA wants
to prevent or lessen problems that result from the consumption of
alcohol and other psychoactive substances. The SFA designs and
implements prevention projects, is involved in health policy and
psychosocial research. The SFA is a private, politically independent
organization with charitable purposes.

Synchronize the internal clock

By air, it goes in a few hours over many time zones
Some swear by melatonin, Viagra or sunbathing to jet lag. FOCUS Online
explains why a time shift causes problems and what can help it.

A jet lag occurs when one has time to shift the body is not adjusted
to the new day-and night-time symptoms and therefore occur. The signs
include headache, fatigue, stomach problems, irritability. "Typical
symptoms of jet lag are marked insomnia," says travel and flight
surgeon Erich Kroeger.

The phenomenon is particularly evident after a period of transition,
about the time in spring or summer, back to the normal time in the
fall. Or it occurs after long-distance journeys, which lead to a
different time zone. In the second case, it takes each time zone with
a one hour time difference is about half a day, until the organism has
become accustomed to the other time, run internal and external clock
synchronization again, says the expert. After a journey from Berlin to
New York (six hour time difference) of jet lag lasts about three days.

Clock daylight

Scientifically explained the reason for it in a rice grain-sized cell
structure in the brain, called the suprachiasmatic nucleus (SCN),
located in the area behind the nose. As the SCN circadian clock
regulates many genes through different processes in the organism -
including body temperature, blood pressure, hunger, thirst, brain and
muscle power. In addition, the SCN sends certain signals to the pineal
gland, which secretes then depending on time of day or sleep-wake
hormones. The decisive factor is light. A change in the usual rhythm,
it is so unusual as to light or dark period, the body's clock begins
to stumble.

Expert advice: Prof. Dr. med Erich Kroeger, travel and flight surgeon,
director of the Center for Travel Medicine

Treatment: The body clock adjust quickly

So sleep and digestive disorders, poor concentration and mood swings
are not too pronounced and the jet lag as short as possible failure:
Take advantage of the sunlight as pacesetter for the circadian clock.
Direct sunlight is not necessary. It is enough if you are outdoors
during the day as long as possible.
Try to live at the destination immediately after the new daily rhythm.
Go to there usual time to sleep or are on you.
Natural sleep aids such as valerian, hops and lemon balm help falling asleep.
To be alert to offers of caffeine. He brings the circulation going and
can slow the release of the sleep hormone melatonin. "However, one
should not drink much of it exaggerated," warns expert Erich Kroeger.

sleeping pills and aids

Information on sleeping pills and aids will be published here soon.